Major Histocompatibility Complex Heterozygosity Reduces Fitness in Experimentally Infected Mice
نویسندگان
چکیده
منابع مشابه
Major histocompatibility complex heterozygosity reduces fitness in experimentally infected mice.
It is often suggested that heterozygosity at major histocompatibility complex (MHC) loci confers enhanced resistance to infectious diseases (heterozygote advantage, HA, hypothesis), and overdominant selection should contribute to the evolution of these highly polymorphic genes. The evidence for the HA hypothesis is mixed and mainly from laboratory studies on inbred congenic mice, leaving the im...
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ژورنال
عنوان ژورنال: Genetics
سال: 2007
ISSN: 1943-2631
DOI: 10.1534/genetics.107.074815